The International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network is a global collaboration of investigators, institutions, community representatives, and other partners organized for the purpose of evaluating prevention and treatment interventions for HIV and HIV-associated complications and co-morbidities in infants, children, and adolescents, and during pregnancy and postpartum through the conduct of high-quality clinical trials. IMPAACT’s vision and overall goal is to end the worldwide HIV epidemic among these populations. To achieve this goal, the IMPAACT Network evaluates novel and durable treatments for both HIV and TB, strategies for antiretroviral treatment (ART)-free remission, and strategies to address the complications and co-morbidities affecting these populations of interest with or at risk of HIV.

IMPAACT was formed in 2006 through a merger of investigators from the Pediatric AIDS Clinical Trials Group (PACTG) and the Perinatal Scientific Working Group of the HIV Prevention Trials Network (HPTN). Following re-competition of leadership grants in 2013–2014, a new seven-year funding cycle began in December 2014. The Network was successfully re-competed in 2020, with a new seven-year funding cycle beginning in December 2020. The Network is directed by a leadership group led by Chair, Sharon Nachman, MD, of the University of New York at Stony Brook, International Vice Chair, Philippa Musoke, MD, of the Makerere University-Johns Hopkins University Research Collaboration, and Domestic Vice Chair, Patricia Flynn, MD, of St. Jude Children’s Research Hospital.

The central resources of the IMPAACT Network include:

  • Leadership and Operations Center (LOC), located at Johns Hopkins University (JHU) and FHI 360
  • Statistical and Data Management Center (SDMC), located at the Harvard T.H. Chan School of Public Health and Frontier Science Foundation
  • Laboratory Center (LC), located at the University of California Los Angeles (UCLA)

These groups coordinate closely with each other in the development, implementation, and oversight of Network studies and other Network activities. Overall support and funding for IMPAACT is provided by the National Institute of Allergy and Infectious Diseases (NIAID), with support and co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Mental Health (NIMH), all components of the United States National Institutes of Health (NIH).