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The IMPAACT Network has updated several sections of the Network Manual of Procedures (MOP). Individual sections and a combined version are available on the website at

Please refer to the “Overview of Section Contents and Identification of Current Section Versions” for information on key updates incorporated into the sections. Of note, there are five updated sections included, which are identified as Version 3.1, dated 14 May 2021:

  • Section 3 (Good Documentation Practices)
  • Section 7 (General Policies and Procedures)
  • Section 8 (Human Subjects Consideration)
  • Section 12 (Study Implementation)
  • Section 14 (Study Close-out)

Please contact the Operations Center ( if you have any questions about the MOP updates or issues accessing the files. Please distribute this information widely to ensure awareness of and access to the updated files. Copies of previous versions of the IMPAACT MOP should be removed from circulation at your location and replaced with copies of the newly released versions.