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1077BF / PROMISE 1077BF

Breastfeeding Version of the PROMISE Study: Promoting Maternal and Infant Survival Everywhere

Study Status

Participants Off Study and Primary Analysis Completed

DAIDS Number

10777

IND Number

107,507

Clinical Trials Link

Summary

1077BF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE) Protocol is a research protocol of the IMPAACT network designed to address in an integrated and comprehensive fashion three critical questions currently facing HIV-infected pregnant and postpartum women and their infants:

  • What is the optimal intervention for the prevention of antepartum and intrapartum transmission of HIV?
  • What is the optimal intervention for the prevention of postpartum transmission in breastfeeding (BF) infants?
  • What is the optimal intervention for the preservation of maternal health after the risk period for prevention of mother-to-child-transmission ends (either at delivery or cessation of BF)?

This version of the PROMISE protocol (IMPAACT 1077BF) is intended for those sites where the standard method of infant feeding is breastfeeding.

 

> Read more about PROMISE study results

Study documents:

docx
129.75 KB
pdf
1.8 MB
17 November 2020

Manual of Procedures

Abstracts

Systemic inflammation in pregnant women with HIV: relationship with preterm delivery and HIV treatment regimen

Conference

International Workshop on HIV Pediatrics

Study

1077BF

Authors

Rupak Shivakoti, Mark Giganti, Michael Lederman, Rachel Ketchum, Sean Brummel, Daniela Moisi, Sufia Dadabhai, Daya Moodley, Avy Violari, Lameck Chinula, Maxensia Owor, Amita Gupta, Judith S. Currier, Taha E Taha, Mary Glenn Fowler, PROMISE study team

Impact of Maternal Hepatitis B Virus Co-infection on Pregnancy and Infant Outcomes in the Promoting Maternal and Infant Survival Everywhere (PROMISE) Study

Conference

CROI 2022

Study

1077BF, 1077FF

Authors

Flavia Matovu Kiweewa, Camlin Tierney, Audrey Chang, Daya Moodley, Vani Govender, Tichaona Vhembo, Neaka Mohtashemi, Hannah Ship, Philippa Musoke, Dingase Dula, Kathy George, Nahida Chakhtoura, Marion G Peters, Mary G Fowler, Judith S Currier, Debika Bhattacharya

Self-Reported Antiretroviral Adherence: Association with Maternal Viral Load Suppression in HIV-1-Infected Postpartum Women in Promoting Maternal and Infant Survival Everywhere (PROMISE): randomized, open label trial in Sub-Saharan Africa and India

Conference

IAS 2021

Study

1077BF, 1077FF

Authors

Neetal Nevrekar, Kevin Butler, David E. Shapiro, Patience Atuhaire, Taha E Taha, Bonus Makanani, Lameck Chinula, Maxie Owor, Daya Moodley, Tsungai Chipato, Pat Flynn, Judy Currier, Mary Glenn Fowler, Amita Gupta, Nishi Suryavanshi

Preterm birth, breastfeeding, antenatal ARV regimen and 24-month HIV-free survival

Study

1077BF (N), 1077FF (N)

Authors

Mary Glenn Fowler, Mauricio Pinilla, Sufia Dadabhai, Maxie Owor, Lynda Stranix-Chibanda, Patricia Flynn, Taha E. Taha, Lameck Chinula, Avy Violari, Daya Moodley, Katie McCarthy, Renee Browning, Sean Brummel, Lynne Mofenson, for the PROMISE 1077BF/FF team

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens

Conference

IAS 2017

Study

1077BF, 1077FF

Authors

D Bhattacharya, A Gupta, C Tierney, S Huang, M Peters, T Chipato, F Martinson, D Dula, K George, N Chakhtoura, KL Klingman, D Gnanashanmugam, J Currier, MG Fowler

Manuscripts