HIV Complications and Co-Morbidities

The IMPAACT HIV Complications & Co-morbidities Scientific Committee aims to determine optimal and feasible methods for the prevention and management of co-infections and co-morbidities of HIV infection and its treatment. Neurocognitive impairment, chronic immune activation/inflammation, serious HIV co-infections and toxicities of long-term ARV exposure are significant causes of disease in these vulnerable populations and need to be addressed to reduce and prevent serious morbidities. Priorities include evaluation of:

  • Interventions to prevent or treat cognitive impairment and mood disorders in HIV-infected children.
  • The importance of the inflammatory state characteristic of HIV infection in children during growth and development and evaluation of interventions to alter it and related complications.
  • Signals of adverse events (AEs) occurring in HIV-infected children in long term follow-up as a result of HIV infection or treatment for HIV infection and its complications.
  • Vaccines for infectious agents other than HIV that cause significant morbidity and/or mortality in HIV-exposed infants and HIV-infected pregnant women, children, and adolescents.

Committee Contacts

Chair: Allison Agwu
Operations Center: Jen Libous and Sarah Buisson



Studies Within This Research Area